Reduced aquaporin-1 transcript expression in colorectal carcinoma is associated with promoter hypermethylation

Aquaporin-1 (AQP1) is a homo-tetrameric transmembrane protein that facilitates rapid movement of water and ions across cell membranes. The clinical significance of AQP1 expression in colorectal carcinoma (CRC) is controversial. The aim of this study was to investigate the prognostic significance of...

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Bibliographic Details
Published in:Epigenetics 2019-02, Vol.14 (2), p.158-170
Main Authors: Smith, Eric, Tomita, Yoko, Palethorpe, Helen M., Howell, Stuart, Nakhjavani, Maryam, Townsend, Amanda R., Price, Timothy J., Young, Joanne P., Hardingham, Jennifer E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aquaporin 1 - genetics
aquaporin-1 (AQP1)
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
DNA Methylation
Down-Regulation
expression
Female
Gene Expression Regulation, Neoplastic
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Prognosis
Promoter Regions, Genetic
Research Paper
Survival Analysis
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Summary:Aquaporin-1 (AQP1) is a homo-tetrameric transmembrane protein that facilitates rapid movement of water and ions across cell membranes. The clinical significance of AQP1 expression in colorectal carcinoma (CRC) is controversial. The aim of this study was to investigate the prognostic significance of AQP1 transcript expression and the association between expression and promoter methylation in normal colonic mucosa, CRC tissues and cell lines. Analysis of publicly available datasets from The Cancer Genome Atlas revealed that AQP1 expression was significantly decreased in CRC compared to normal mucosa (12.7 versus 33.3 respectively, P
ISSN:1559-2294
1559-2308
DOI:10.1080/15592294.2019.1580112