Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes

Sex-linked differences in mitochondrial ATP production, enzyme activities, and reactive oxygen species generation have been reported in multiple tissue and cell types. While the effects of reproductive hormones underlie many of these differences, regulation of sexually dimorphic mitochondrial functi...

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Bibliographic Details
Published in:Epigenetics 2022-12, Vol.17 (12), p.1573-1589
Main Authors: King, Dillon E., Sparling, Anna Clare, Lloyd, Dillon, Satusky, Matthew Joseph, Martinez, Mackenzie, Grenier, Carole, Bergemann, Christina Michelle, Maguire, Rachel, Hoyo, Cathrine, Meyer, Joel Newman, Murphy, Susan K.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate
DNA Methylation
Female
Genes, Mitochondrial
Hormones
Humans
in utero smoke exposure
Male
Maternal Exposure
mitochondria
Reactive Oxygen Species
Research Paper
Sex differences
Sex Factors
Tobacco Smoke Pollution
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Summary:Sex-linked differences in mitochondrial ATP production, enzyme activities, and reactive oxygen species generation have been reported in multiple tissue and cell types. While the effects of reproductive hormones underlie many of these differences, regulation of sexually dimorphic mitochondrial function has not been fully characterized. We hypothesized that sex-specific DNA methylation contributes to sex-specific expression of nuclear genes that influence mitochondrial function. Herein, we analysed DNA methylation data specifically focused on nuclear-encoded mitochondrial genes in 191 males and 190 females. We found 596 differentially methylated sites (DMSs) (FDR p
ISSN:1559-2294
1559-2308
DOI:10.1080/15592294.2022.2043591