RNA modification m 6 Am: the role in cardiac biology

Epitranscriptomic modifications have recently emerged into the spotlight of researchers due to their vast regulatory effects on gene expression and thereby cellular physiology and pathophysiology. N ,2'-O-dimethyladenosine (m Am) is one of the most prevalent chemical marks on RNA and is dynamic...

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Bibliographic Details
Published in:Epigenetics 2023-12, Vol.18 (1), p.2218771
Main Authors: Benak, Daniel, Kolar, Frantisek, Zhang, Lu, Devaux, Yvan, Hlavackova, Marketa
Format: Article
Language:English
Subjects:
Adenosine - metabolism
Biology
DNA Methylation
RNA - metabolism
RNA, Messenger - genetics
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Summary:Epitranscriptomic modifications have recently emerged into the spotlight of researchers due to their vast regulatory effects on gene expression and thereby cellular physiology and pathophysiology. N ,2'-O-dimethyladenosine (m Am) is one of the most prevalent chemical marks on RNA and is dynamically regulated by writers (PCIF1, METTL4) and erasers (FTO). The presence or absence of m Am in RNA affects mRNA stability, regulates transcription, and modulates pre-mRNA splicing. Nevertheless, its functions in the heart are poorly known. This review summarizes the current knowledge and gaps about m Am modification and its regulators in cardiac biology. It also points out technical challenges and lists the currently available techniques to measure m Am. A better understanding of epitranscriptomic modifications is needed to improve our knowledge of the molecular regulations in the heart which may lead to novel cardioprotective strategies.
ISSN:1559-2294
1559-2308
DOI:10.1080/15592294.2023.2218771