Prevalence of G6PD deficiency in Thai blood donors, the characteristics of G6PD deficient blood, and the efficacy of fluorescent spot test to screen for G6PD deficiency in a hospital blood bank setting

Transfusion of blood from glucose-6-phosphate dehydrogenase (G6PD) enzyme deficient donors could cause a potentially unfavorable outcome, especially in newborns and those with hemoglobinopathies. To determine the prevalence of G6PD deficiency in Thai blood donors, the characteristics of G6PD deficie...

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Bibliographic Details
Published in:Hematology (Luxembourg) 2022-12, Vol.27 (1), p.208-213
Main Authors: Rojphoung, Phinyada, Rungroung, Thongbai, Siriboonrit, Usanee, Vejbaesya, Sasijit, Permpikul, Parichart, Kittivorapart, Janejira
Format: Article
Language:English
Subjects:
Blood Banks
Blood Donors
Erythrocytes - pathology
Female
fluorescent spot test
G6PD deficiency
G6PD deficient blood
Glucosephosphate Dehydrogenase Deficiency - blood
Glucosephosphate Dehydrogenase Deficiency - diagnosis
Glucosephosphate Dehydrogenase Deficiency - epidemiology
Hemolysis
hospital blood bank setting
Humans
Male
Prevalence
Thai blood donors
Thailand - epidemiology
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Summary:Transfusion of blood from glucose-6-phosphate dehydrogenase (G6PD) enzyme deficient donors could cause a potentially unfavorable outcome, especially in newborns and those with hemoglobinopathies. To determine the prevalence of G6PD deficiency in Thai blood donors, the characteristics of G6PD deficient blood, and the efficacy of fluorescent spot test (FST) to screen for G6PD deficiency in a hospital blood bank setting. Blood samples were obtained from 514 Thai blood donors who donated blood at Siriraj Hospital (Bangkok, Thailand) during December 2020-February 2021. G6PD deficiency status was screened using FST, and in vitro hemolysis of red blood cell parameters of G6PD deficient blood units was compared with those of normal control units at different time points during 35 days of refrigerated storage. The prevalence of G6PD deficiency was 7.59% (35 [8.73%] males, 4 [3.54%] females). The sensitivity of FST was 100% (95% confidence interval [CI]: 90.97-100%), and the specificity was 99.58% (95%CI: 98.49-99.95%). In vitro hemolysis was not significantly different between G6PD deficiency and normal controls. The prevalence of G6PD deficiency in this study was 7.59%. FST was demonstrated to be an effective and reliable method for G6PD deficiency screening among Thai blood donors in a hospital blood bank setting.
ISSN:1607-8454
1607-8454
DOI:10.1080/16078454.2022.2027082