Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stress-induced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory...

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Bibliographic Details
Published in:Journal of Taibah University for Science 2018-05, Vol.12 (3), p.273-284
Main Authors: Azman, Khairunnuur Fairuz, Zakaria, Rahimah, Othman, Zahiruddin, Abdul Aziz, Che Badariah
Format: Article
Language:English
Subjects:
ageing
antioxidant
Honey
oxidative
stress
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Summary:The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stress-induced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory impairment, increased brain oxidation indices, and decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3 hippocampal areas in both young and aged rats. The stressed rats treated with Tualang honey showed a significant decrease in stress hormone levels and brain oxidation indices, and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang honey was more prominent in young than aged rats. These results suggest the neuroprotective effects of Tualang honey against oxidative stress and memory decline due to stress exposure and/or ageing through its antioxidant property.
ISSN:1658-3655
1658-3655
DOI:10.1080/16583655.2018.1465275