Synthesis and characterization of n-hydroxyalkyl and oxazolinyl ethionamide derivatives

Multidrug-resistant tuberculosis (MDR-TB) is a serious problem worldwide, especially in people living with human immunodeficiency virus. In considering the MDR-TB problem, ethionamide (ETH) is a structural analog of isoniazid that is typically used when the patient exhibits resistance to the front-l...

Full description

Saved in:
Bibliographic Details
Published in:Journal of sulfur chemistry 2008-04, Vol.29 (2), p.145-149
Main Authors: Cardoso, Sílvia H., Vieira De Almeida, Mauro, Vitor De Assis, João, Diniz, Renata, Speziali, Nivaldo L., De Souza, Marcus V.N.
Format: Article
Language:English
Subjects:
ethionamide
oxazolinyl nucleus
tuberculosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multidrug-resistant tuberculosis (MDR-TB) is a serious problem worldwide, especially in people living with human immunodeficiency virus. In considering the MDR-TB problem, ethionamide (ETH) is a structural analog of isoniazid that is typically used when the patient exhibits resistance to the front-line drugs, being one of the most frequently used drugs, for the treatment of drug-resistant tuberculosis. Due to the importance of ETH in TB treatment, the aim of our work was the synthesis and characterization of oxazolinyl (1,2) and N-hydroxyalkyl (3-5) ETH derivatives.
ISSN:1741-5993
1741-6000
DOI:10.1080/17415990701845963