A new X-ray contrast agent based on highly stable gum arabic-gold nanoparticles synthesised in deep eutectic solvent

This paper reports a novel method of fabricating gum arabic coated gold nanoparticles (GA-GNPs) synthesised in a deep eutectic solvent (DES) for use as a new X-ray contrast agent. GA-GNPs were prepared simply by mixing a solution of 0.01% DES, GA and tetra chloroauric (III) acid at room temperature....

Full description

Saved in:
Bibliographic Details
Published in:Journal of experimental nanoscience 2015-08, Vol.10 (12), p.911-924
Main Authors: Shahidi, Shoaleh, Iranpour, Shiva, Iranpour, Pooya, Alavi, Ali Asghar, Mahyari, Farzaneh Aghakhani, Tohidi, Maryam, Safavi, Afsaneh
Format: Article
Language:English
Subjects:
deep eutectic solvent
gold nanoparticles
gum arabic
in vitro study
X-ray contrast agent
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This paper reports a novel method of fabricating gum arabic coated gold nanoparticles (GA-GNPs) synthesised in a deep eutectic solvent (DES) for use as a new X-ray contrast agent. GA-GNPs were prepared simply by mixing a solution of 0.01% DES, GA and tetra chloroauric (III) acid at room temperature. DES was prepared using choline chloride (ChCl), gallic acid and glycerol as the precursors. A complete characterisation study of GA-GNPs was undertaken using transmission electron microscopy, dynamic light scattering, X-ray diffraction analysis. In vitro study of the as-prepared GA-GNPs revealed the high potential of these nanoparticles as X-ray contrast agents. Compared with the common clinically available CT contrast agent, Visipaque, the synthesised GA-GNPs showed more than three fold X-ray attenuation coefficient. GA-GNPs were found to be remarkably stable in biological media. The development of such nontoxic, biocompatible nanostructures could be an advancement in diagnostic nanomedicine.
ISSN:1745-8080
1745-8099
DOI:10.1080/17458080.2014.933493