Dynamical questions in volume transmission

In volume transmission (or neuromodulation) neurons do not make one-to-one connections to other neurons, but instead simply release neurotransmitter into the extracellular space from numerous varicosities. Many well-known neurotransmitters including serotonin (5HT), dopamine (DA), histamine (HA), Ga...

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Bibliographic Details
Published in:Journal of biological dynamics 2023-12, Vol.17 (1), p.2269986-2269986
Main Authors: Cruikshank, Allison, Nijhout, H. Frederik, Best, Janet, Reed, Michael
Format: Article
Language:English
Subjects:
Acetylcholine
Axons
Brain
chemistry
comodulation
Dopamine
dynamics
Histamine
Mathematics
Neostriatum
Neuromodulation
Neurotransmitters
Serotonin
Volume transmission
γ-Aminobutyric acid
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Summary:In volume transmission (or neuromodulation) neurons do not make one-to-one connections to other neurons, but instead simply release neurotransmitter into the extracellular space from numerous varicosities. Many well-known neurotransmitters including serotonin (5HT), dopamine (DA), histamine (HA), Gamma-Aminobutyric Acid (GABA) and acetylcholine (ACh) participate in volume transmission. Typically, the cell bodies are in one volume and the axons project to a distant volume in the brain releasing the neurotransmitter there. We introduce volume transmission and describe mathematically two natural homeostatic mechanisms. In some brain regions several neurotransmitters in the extracellular space affect each other's release. We investigate the dynamics created by this comodulation in two different cases: serotonin and histamine; and the comodulation of 4 neurotransmitters in the striatum and we compare to experimental data. This kind of comodulation poses new dynamical questions as well as the question of how these biochemical networks influence the electrophysiological networks in the brain.
ISSN:1751-3758
1751-3766
DOI:10.1080/17513758.2023.2269986