Efficient microwave-promoted synthesis of glucuronic and galacturonic acid derivatives using sulfuric acid impregnated on silica

Monomode microwave-assisted syntheses of d-glucuronic and d-galacturonic acid derivatives are reported in the presence of a solid acid catalyst, consisting of sulfuric acid loaded onto silica. This approach affords a variety of surface-active monoglycosylated glucofuranosidurono-6,3-lactones and dis...

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Bibliographic Details
Published in:Green chemistry letters and reviews 2012-06, Vol.5 (2), p.179-186
Main Authors: Richel, Aurore, Nicks, François, Laurent, Pascal, Wathelet, Bernard, Wathelet, Jean-Paul, Paquot, Michel
Format: Article
Language:English
Subjects:
Carbohydrates
Chemistry
Chimie
Heterogeneous catalysis
Microwave chemistry
Physical, chemical, mathematical & earth Sciences
Physique, chimie, mathématiques & sciences de la terre
Silica
Supported catalysts
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Summary:Monomode microwave-assisted syntheses of d-glucuronic and d-galacturonic acid derivatives are reported in the presence of a solid acid catalyst, consisting of sulfuric acid loaded onto silica. This approach affords a variety of surface-active monoglycosylated glucofuranosidurono-6,3-lactones and disubstituted galacturonic adducts in excellent yields in less than 10 min at 85°C. This study illustrates the application of microwave heating mode, in combination with a cost-effective solid catalyst, as an efficient, selective, and eco-friendly methodology in carbohydrate chemistry.
ISSN:1751-8253
1751-7192
1751-7192
DOI:10.1080/17518253.2011.607852