Fever of Unknown Origin Due to Inflammatory Pseudotumour of Lymph Nodes

The clinical features of inflammatory pseudotumour of lymph nodes, a distinct non-malignant histopathological entity firstly described in 1988, are summarized based upon a detailed analysis of 4 personal cases and 47 cases reported in the literature. The mean age of the patients is 38 years (range 8...

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Bibliographic Details
Published in:Acta clinica belgica (English ed. Online) 1998-12, Vol.53 (6), p.367-370
Main Authors: Knockaert, D.C., Schuermans, A., Vlayen, J., Dewolf-Peeters, Chris, Bobbaers, H.J.
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Female
Fever of Unknown Origin - etiology
Follow-Up Studies
Granuloma, Plasma Cell - complications
Granuloma, Plasma Cell - drug therapy
Granuloma, Plasma Cell - pathology
Granuloma, Plasma Cell - surgery
Humans
Indomethacin - therapeutic use
Lymph Nodes - pathology
Lymphatic Diseases - complications
Lymphatic Diseases - drug therapy
Lymphatic Diseases - pathology
Lymphatic Diseases - surgery
Male
Prognosis
Recurrence
Remission, Spontaneous
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Summary:The clinical features of inflammatory pseudotumour of lymph nodes, a distinct non-malignant histopathological entity firstly described in 1988, are summarized based upon a detailed analysis of 4 personal cases and 47 cases reported in the literature. The mean age of the patients is 38 years (range 8 to 82 years) and there is no gender predilection. One third present with asymptomatic lymphadenopathy and 47% present with fever, nearly all meeting the criteria of fever of unknown origin. Abdominal complaints are occasionally present. Intermittence of symptoms is common. Hepatosplenomegaly is unusual. All lymph node areas may be involved but abnormalities are mostly confined to one or two anatomic regions. No extranodal involvement has been reported although inflammatory pseudotumour may occur in several organs with similar morphological features and identical signs of inflammations. Routine blood tests are normal except for signs of inflammation. The lesions are Galliumavid. Diagnosis is based upon typical histopathological features. The prognosis is favorable and surgical resection frequently leads to cure. Spontaneous resolution of symptoms has been reported and non-steroidal anti-inflammatory drugs may suppress the clinical manifestations.
ISSN:1784-3286
2295-3337
DOI:10.1080/17843286.1998.11754193