Hepatotoxicity with High-Dose Green Tea Extract: Effect of Catechol-O-Methyltransferase and Uridine 5'-Diphospho-glucuronosyltransferase 1A4 Genotypes

The predominant catechin in green tea, epigallocatechin gallate (EGCG), may be hepatotoxic in high doses. Our objective was to investigate the influence of catechol-O-methyltransferase (COMT) and uridine 5'-diphospho-glucuronosyltransferase 1A4 (UGT1A4) genotypes on changes in liver injury biom...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dietary supplements 2023, Vol.ahead-of-print (ahead-of-print), p.1-20
Main Authors: Acosta, Laura, Byham-Gray, Laura, Kurzer, Mindy, Samavat, Hamed
Format: Article
Language:English
Subjects:
alanine transaminase
Antioxidants
aspartate aminotransferases
Camellia sinensis
Catechin
catechol O-methyltransferase
Catechol O-Methyltransferase - genetics
chemical and drug induced liver injury
Chemical and Drug Induced Liver Injury - genetics
Dietary Supplements
epigallocatechin gallate
Female
Genotype
glucuronosyltransferase
Glucuronosyltransferase - genetics
Humans
Plant Extracts - toxicity
tea
Tea - toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The predominant catechin in green tea, epigallocatechin gallate (EGCG), may be hepatotoxic in high doses. Our objective was to investigate the influence of catechol-O-methyltransferase (COMT) and uridine 5'-diphospho-glucuronosyltransferase 1A4 (UGT1A4) genotypes on changes in liver injury biomarkers in response to long-term, high-dose green tea extract (GTE) supplementation among postmenopausal women. A secondary analysis was conducted using data from the Minnesota Green Tea Trial (N = 1,075), in which participants were randomized to consume high-dose GTE (843 mg/day EGCG) or placebo capsules for 12 months. Analysis of covariance adjusting for potential confounders was performed to examine changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST: ALT ratio, and alkaline phosphatase from baseline to months 3, 6, 9, and 12 across COMT and UGT1A4 genotypes. Mean age and BMI within the GTE group (n = 400) were 59.8 yrs and 25.1 kg/m 2 , respectively, and 98% of subjects were white. From baseline to month 3, mean AST: ALT ratio change was +1.0% in the COMT (rs4680) A/G genotype versus −4.8% in the A/A genotype (p = 0.03). From baseline to months 6 and 9, respectively, mean ALT change was +78.1% and +82.1% in the UGT1A4 (rs6755571) A/C genotype versus +28.0% and +30.1% in the C/C genotype (p 
ISSN:1939-0211
1939-022X
DOI:10.1080/19390211.2022.2128501