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Follicular fat-soluble vitamins as markers of oocyte competency

The main aim of this prospective study was to investigate the effect of the concentration of fat-soluble vitamins A, D, E and K in individual follicles on oocyte quality and developmental competence. The analysis was performed on 313 follicular fluid (FF) samples from 50 patients undergoing ovarian...

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Published in:Systems biology in reproductive medicine 2020-03, Vol.66 (2), p.112-121
Main Authors: Skowrońska, Patrycja, Kunicki, Michał, Pastuszek, Ewa, Konieczna, Lucyna, Bączek, Tomasz, Łukaszuk, Krzysztof
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container_title Systems biology in reproductive medicine
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creator Skowrońska, Patrycja
Kunicki, Michał
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Łukaszuk, Krzysztof
description The main aim of this prospective study was to investigate the effect of the concentration of fat-soluble vitamins A, D, E and K in individual follicles on oocyte quality and developmental competence. The analysis was performed on 313 follicular fluid (FF) samples from 50 patients undergoing ovarian stimulation with intracytoplasmic sperm injection. We demonstrated that the mean concentration of individual vitamins in FF correlated with their level in serum (p < 0.0001). The levels of vitamin D in FF were higher than in serum, while the opposite was observed for other analyzed vitamins. We did not observe a correlation between FF vitamin D concentration with fertilization success. However, we observed its association with embryo development status on day 3. Moreover, we showed a statistically significant negative correlation between the mean day 5 embryo score and the concentration of vitamin D in serum (rS = −0.68 p = 0.01) and follicular fluid (rS = −0.71 p = 0.01). Our study showed that FF concentration of vitamin A and E was helpful in the prediction of fertilization success of each individual oocyte. Moreover, vitamin A and E concentrations in FF were associated with status of embryo development on the third day of culture. Vitamin A was also associated with the embryo quality on day 2 and the embryo development status on day 5 after fertilization. In conclusion, a combination of FF vitamin analysis and routine morphological assessment could allow for a more accurate and sensitive method of determining embryonic developmental competence and enable the selection of a better embryo to transfer and perhaps translating into an increased chance of pregnancy. Abbreviations: in vitro fertilization: IVF; anti-Mullerian hormone: AMH; follicular fluid: FF; intracytoplasmic sperm injection: ICSI; top quality: TQ; vitamin D binding globulin level: VDBP; assisted reproductive technology: ART
doi_str_mv 10.1080/19396368.2020.1718244
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Adult
Biomarkers - analysis
embryo development
Embryonic Development
Fat-soluble vitamins
Female
Fertilization in Vitro
fertilization potential
Follicular Fluid - chemistry
Humans
Infertility, Female
Infertility, Male
Male
oocyte quality
Oocytes - physiology
Ovarian Follicle - chemistry
Predictive Value of Tests
Prospective Studies
Sperm Injections, Intracytoplasmic
Treatment Outcome
Vitamins - analysis
title Follicular fat-soluble vitamins as markers of oocyte competency
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