Assessment of elimination profile of albendazole residues in fish

Few drugs are specifically regulated for aquaculture. Thus this study considered albendazole (ABZ) as a potential drug for use in fish, which, however, is not yet regulated for this application. ABZ is a broad-spectrum anthelmintic approved for farmed ruminants and recently considered for treatment...

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Bibliographic Details
Published in:Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Chemistry, analysis, control, exposure & risk assessment, 2018-01, Vol.35 (1), p.77-85
Main Authors: Busatto, Zenaís, de França, Welliton Gonçalves, Cyrino, José Eurico Possebon, Paschoal, Jonas Augusto Rizzato
Format: Article
Language:English
Subjects:
Albendazole
Albendazole - analysis
Albendazole - metabolism
Animal products
Animals
Anthelmintic agents
Anthelmintics - analysis
Anthelmintics - metabolism
Aquaculture
Body weight
Characidae - metabolism
Depletion
drug depletion
Drug Residues - analysis
Drug Residues - metabolism
Drugs
Fillets
Fish
Fish parasites
Food safety
Metabolites
Molecular Structure
Parasites
Piaractus mesopotamicus
Residues
Time Factors
veterinary drug residues
withdrawal time
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Summary:Few drugs are specifically regulated for aquaculture. Thus this study considered albendazole (ABZ) as a potential drug for use in fish, which, however, is not yet regulated for this application. ABZ is a broad-spectrum anthelmintic approved for farmed ruminants and recently considered for treatment of fish parasites. It is the subject of careful monitoring because of potential residues in animal products. This study evaluated the depletion of ABZ and its main known metabolites: albendazole sulfoxide - ABZSO, albendazole sulfone - ABZSO 2 and albendazole amino sulfone - ABZ-2-NH 2 SO 2 , in the fillets of the Neotropical Characin pacu, Piaractus mesopotamicus, which were fed diets containing 10 mg ABZ kg −1 body weight in a single dose. Fish were euthanised at 8, 12, 24, 48, 72, 96 and 120 hours after medication and the depletion profiles of ABZ, each metabolite and the sum of all marker residues were assessed and evaluated taking into account methodological variations regarding determination of the maximum residue limits adopted by different international regulating agencies for estimation of the withdrawal period (WP). The estimated WPs ranged from 2 to 7 days.
ISSN:1944-0049
1944-0057
DOI:10.1080/19440049.2017.1400186