In vitro biotransformation of OA-group and PTX-group toxins in visceral and non-visceral tissues of Mytilus chilensis and Ameghinomya antiqua

Lipophilic marine toxins (LMTs) are made up of multiple groups of toxic analogues, which are characterised by different levels of cellular and toxic action. The most prevalent groups in the southern Pacific zone are: a) okadaic acid group (OA-group) which consists of okadaic acid (OA) and dinophysis...

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Published in:Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Chemistry, analysis, control, exposure & risk assessment, 2020-07, Vol.37 (7), p.1216-1228
Main Authors: Oyaneder-Terrazas, Javiera, Polanco, Cassandra, Figueroa, Diego, Barriga, Andres, García, Carlos
Format: Article
Language:English
Subjects:
acyl derivatives
Ameghinomya antiqua
Animals
Biotransformation
Bivalvia - chemistry
Bivalvia - metabolism
Chile
Chromatography, Liquid
Digestive glands
Endemic species
Furans - analysis
Furans - metabolism
Lipophilic
Macrolides - analysis
Macrolides - metabolism
Mollusks
Mussels
Mytilus - chemistry
Mytilus - metabolism
Mytilus chilensis
Okadaic acid
Okadaic Acid - analogs & derivatives
Okadaic Acid - analysis
Okadaic Acid - metabolism
Okadaic acid-group
pectenotoxin-2sa
pectenotoxin-group
Shellfish
Tandem Mass Spectrometry
Toxicology
Toxins
transformation
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Summary:Lipophilic marine toxins (LMTs) are made up of multiple groups of toxic analogues, which are characterised by different levels of cellular and toxic action. The most prevalent groups in the southern Pacific zone are: a) okadaic acid group (OA-group) which consists of okadaic acid (OA) and dinophysistoxin-1 (DTX-1); and, b) pectenotoxin-2 (PTX2) group which consists of pectenotoxin-2 (PTX-2). The main objective of our study was to examine in vitro biotransformation of OA-group and PTX-group in the tissues of two endemic species of bivalves from southern Chile; blue mussels (Mytilus chilensis) and clams (Ameghinomya antiqua). The biotransformation processes of both groups were only detected in the digestive glands of both species using LC-MS/MS. The most frequently detected analogues were acyl derivatives (≈2.0 ± 0.1 μg ml −1 ) for OA-group and PTX-2SA (≈1.4 ± 0.1 μg ml −1 ) for PTX-group, with a higher percentage of biotransformation for OA-group (p
ISSN:1944-0049
1944-0057
DOI:10.1080/19440049.2020.1750710