Probiotic Lactobacillus reuteri has antifungal effects on oral Candida species in vitro

Background: An alternative approach for managing Candida infections in the oral cavity by modulating the oral microbiota with probiotic bacteria has been proposed. Objective: The aim was to investigate the antifungal potential of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA...

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Bibliographic Details
Published in:Journal of oral microbiology 2017-01, Vol.9 (1), p.1274582-8
Main Authors: Jørgensen, Mette Rose, Kragelund, Camilla, Jensen, Peter Østrup, Keller, Mette Kirstine, Twetman, Svante
Format: Article
Language:English
Subjects:
Agglomeration
Antifungal activity
antimycotic
Bacteria
Beneficial bacteria
Candida
Candida albicans
Candida krusei
Candida parapsilosis
candidiasis
co-aggregation
Fungicides
growth inhibition
Hydrogen peroxide
Hydrogen production
Infections
Inhibition
Ions
Lactobacilli
Lactobacillus
Lactobacillus reuteri
Life assessment
Mass spectrometry
Microbiota
Microorganisms
Oral cavity
Original
Oxidative stress
pH effects
Probiotics
Saccharomyces cerevisiae
Scientific imaging
Species
Spectrophotometry
Statistical analysis
Strains (organisms)
yeast
Yeasts
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Summary:Background: An alternative approach for managing Candida infections in the oral cavity by modulating the oral microbiota with probiotic bacteria has been proposed. Objective: The aim was to investigate the antifungal potential of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) against six oral Candida species (C. albicans, C. glabrata, C. krusei, C. tropicalis, C. dubliniensis, and C. parapsilosis). Design: The lactobacilli were tested for their ability to co-aggregate with and inhibit the growth of the yeasts assessed by spectrophotometry and the agar overlay inhibition assay. Additionally, the pH was evaluated with microsensors, and the production of hydrogen peroxide (H2O2) by the lactobacilli was verified. Results: Both L. reuteri strains showed co-aggregation abilities with the yeasts. The lactobacilli almost completely inhibited the growth of C. albicans and C. parapsilosis, but did not affect C. krusei. Statistically significant differences in co-aggregation and growth inhibition capacities between the two L. reuteri strains were observed (p
ISSN:2000-2297
2000-2297
DOI:10.1080/20002297.2016.1274582