Human to animal transmission of influenza A(H1N1)pdm09 in a turkey breeder flock in Norway

Introduction: Routine surveillance samples disclosed seropositivity to influenza A virus (IAV) in a Norwegian turkey breeder flock. Simultaneous reports of influenza-like symptoms in farm workers and a laboratory confirmed influenza A(H1N1)pdm09 (H1N1pdm09) infection in one person led to the suspici...

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Bibliographic Details
Published in:Infection ecology & epidemiology 2017-01, Vol.7 (1), p.1416249-7
Main Authors: Kulberg Sjurseth, Siri, Gjerset, Britt, Bragstad, Karoline, Hungnes, Olav, Wisløff, Helene, Er, Chiek, Valheim, Mette, Løtvedt, Siri M., David, Bruce, Hanssen, Skjalg A., Hauge, Siri H., Hofshagen, Merete
Format: Article
Language:English
Subjects:
Animals
anthroponosis
Antibodies
Antigens
Artificial insemination
Avian flu
Egg production
Eggs
Farms
Farmworkers
Gene sequencing
Genetic analysis
Hemagglutinins
Homology
Houses
Immunoglobulins
Infections
Influenza
Influenza A
Influenza A(H1N1)pdm09
Laboratories
Nucleic acids
Organs
Orthomyxoviridae
pandemic influenza
Pandemics
Phylogenetics
Phylogeny
Poultry
Poultry farming
Reproduction (biology)
Reproductive organs
Serology
Signs and symptoms
Swine flu
turkey
Turkeys
Viruses
Workers
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Summary:Introduction: Routine surveillance samples disclosed seropositivity to influenza A virus (IAV) in a Norwegian turkey breeder flock. Simultaneous reports of influenza-like symptoms in farm workers and a laboratory confirmed influenza A(H1N1)pdm09 (H1N1pdm09) infection in one person led to the suspicion of a H1N1pdm09 infection in the turkeys. Animals and methods: H1N1pdm09 infection was confirmed by a positive haemaggutinin inhibition test using H1N1pdm09 antigens, and detection of H1N1pdm09 nucleic acid in reproductive organs of turkey hens. The flock showed no clinical signs except for a temporary drop in egg production. Previous reports of H1N1pdm09 infection in turkeys suggested human-to-turkey transmission (anthroponosis) during artificial insemination. Results and discussion: The flock remained seropositive to IAV and the homologous H1N1pdm09 antigen throughout the following 106 days, with decreasing seroprevalence over time. IAV was not detected in fertilised eggs or in turkey poults from the farm, however, maternally derived antibodies against H1N1pdm09 were found in egg yolks and in day-old poults. Genetic analyses of haemagglutinin gene sequences from one of the infected farm workers and turkeys revealed a close phylogenetic relationship, and confirmed human-to-turkey virus transmission.
ISSN:2000-8686
2000-8686
DOI:10.1080/20008686.2017.1416249