Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test

The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this st...

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Bibliographic Details
Published in:Infection ecology & epidemiology 2020, Vol.10 (1), p.1821513-1821513
Main Authors: De Marinis, Yang, Sunnerhagen, Torgny, Bompada, Pradeep, Bläckberg, Anna, Yang, Runtao, Svensson, Joel, Ekström, Ola, Eriksson, Karl-Fredrik, Hansson, Ola, Groop, Leif, Gonçalves, Isabel, Rasmussen, Magnus
Format: Article
Language:English
Subjects:
antibody test
Clinical Laboratory Medicine
Clinical Medicine
COVID-19
disease severity and duration
IgM and IgG
Infectious Medicine
Infektionsmedicin
Klinisk laboratoriemedicin
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
SARS-CoV-2
serology assessment
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Summary:The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with 2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level.
ISSN:2000-8686
2000-8686
DOI:10.1080/20008686.2020.1821513