Relationship between low serum vitamin D status and urinary tract infection in children: a case-control study

A link between vitamin D deficiency and susceptibility to bacterial and viral infections has recently been suggested. To investigate a possible association between vitamin D deficiency and urinary tract infection (UTI). A case-control study was undertaken comprising 75 children aged 2-7 years with U...

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Bibliographic Details
Published in:Paediatrics and international child health 2020-07, Vol.40 (3), p.181-185
Main Authors: Mahmoudzadeh, Hashem, Nikibakhsh, Ahmad Ali, Pashapour, Sarvin, Ghasemnejad-Berenji, Morteza
Format: Article
Language:English
Subjects:
25-hydroxyvitamin D
cystitis
pyelonephritis
urinary tract infection
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Summary:A link between vitamin D deficiency and susceptibility to bacterial and viral infections has recently been suggested. To investigate a possible association between vitamin D deficiency and urinary tract infection (UTI). A case-control study was undertaken comprising 75 children aged 2-7 years with UTI (cases) compared with 75 healthy controls in terms of serum 25 hydroxyvitamin D [25(OH)D] levels. Serum 25(OH)D levels were measured using a chemiluminescence assay. For cases, dimercaptosuccinic acid (DMSA) renal scan was used as the gold standard to distinguish between acute lower UTI (cystitis) and acute pyelonephritis. Median (IQR) 25(OH)D levels were lower in the UTI group [14.5 ng/mL (9.4-18.8)] than in the controls [27 ng/mL (22.4-39.0)] (p
ISSN:2046-9047
2046-9055
DOI:10.1080/20469047.2020.1771244