Hepatitis delta coinfection in persons with HIV: misdiagnosis and disease burden in Italy

Hepatitis Delta virus (HDV) causes severe liver disease. Due to similarities in transmission routes, persons living with HIV (PLWH) are at risk of HDV infection. This analysis investigates the prevalence and the long-term clinical outcome of people with HDV in a large cohort of PLWH. We retrieved HB...

Full description

Saved in:
Bibliographic Details
Published in:Pathogens and global health 2023-02, Vol.117 (2), p.181-189
Main Authors: Brancaccio, Giuseppina, Shanyinde, Milensu, Puoti, Massimo, Gaeta, Giovanni B., Monforte, Antonella D'ARMINIO, Vergori, Alessandra, Rusconi, Stefano, Mazzarelli, Antonio, Castagna, Antonella, Antinori, Andrea, Cozzi-Lepri, Alessandro
Format: Article
Language:English
Subjects:
anti-HBV therapy
clinical outcome
Coinfection - epidemiology
Cost of Illness
Diagnostic Errors
hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus
hepatitis delta
Hepatitis Delta Virus
HIV infection
HIV Infections - complications
Humans
Italy
Male
Prevalence
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hepatitis Delta virus (HDV) causes severe liver disease. Due to similarities in transmission routes, persons living with HIV (PLWH) are at risk of HDV infection. This analysis investigates the prevalence and the long-term clinical outcome of people with HDV in a large cohort of PLWH. We retrieved HBsAg ± anti-HDV positive PLWH enrolled from 1997 to 2015 in the multicentre, prospective ICONA study. The primary endpoint was a composite clinical outcome (CCO = having experienced ≥1 of the following: Fib4 score >3.25; diagnosis of cirrhosis; decompensation; hepatocellular carcinoma or liver-related death). Kaplan-Meier curves and unweighted and weighted Cox regression models were used for data analysis. Less than half of HBsAg positive patients had been tested for anti-HDV in clinical practice. After testing stored sera, among 617 HBV/HIV cases, 115 (19%) were anti-HDV positive; 405 (65%) HBV monoinfected; 99 (16%) undeterminate. The prevalence declined over the observation period. HDV patients were more often males, intravenous drug users, HCV coinfected. After a median of 26 months, 55/115 (48%) developed CCO among HDV+; 98/403 (24%) among HBV monoinfected; 18/99 (18%) in HDV unknown (p 
ISSN:2047-7724
2047-7732
DOI:10.1080/20477724.2022.2047551