Profile of adult patients admitted with drug-induced liver injury at a district hospital in Pietermaritzburg, KwaZulu-Natal

Background: Drug-induced liver injury (DILI) can be prevented if diagnosed and treated timeously. The identification and primary prevention of DILI risk factors presents the rational means of reducing hospital costs and mortality. Methods: A retrospective chart review was conducted of clinical in-pa...

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Bibliographic Details
Published in:South African family practice 2019-11, Vol.61 (6), p.223-228
Main Authors: Naicker, K, Rangiah, S
Format: Article
Language:English
Subjects:
Drug-induced liver injury
Hepatitis
HIV
Jaundice
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Summary:Background: Drug-induced liver injury (DILI) can be prevented if diagnosed and treated timeously. The identification and primary prevention of DILI risk factors presents the rational means of reducing hospital costs and mortality. Methods: A retrospective chart review was conducted of clinical in-patient records of all adult patients admitted to Northdale Hospital (NDH) with a diagnosis of DILI. Patients with pre-existing liver disease were excluded. Results: A total of 95 patient files with DILI were reviewed. The burden of DILI at NDH over the two-year period was 0.19%. The average age was 38 years, with a slightly higher female preponderance (62.1%). A lower serum albumin level (mean 21.35 g/dl) was significantly associated with DILI (p 
ISSN:2078-6190
2078-6204
DOI:10.1080/20786190.2019.1657323