NGAL (Neutrophil Gelatinase-Associated Lipocalin) as an early biomarker of nephropathy in patients with type 2 diabetes

Diabetic nephropathy (DN) is a major microvascular diabetic complication representing the key leading reason for end-stage renal disease (ESRD). The current work aimed to evaluate the value of urinary and serum NGAL (neutrophil gelatinase-associating lipocalin), as an early biomarker of DN in subjec...

Full description

Saved in:
Bibliographic Details
Published in:Alexandria journal of medicine 2023-12, Vol.59 (1), p.52-58
Main Authors: Megallaa, Magdy Helmy Zikry, Abdel Salam, Mohamed Said, Saad, Neveen Lewis Mikhael, Ahmed Altair, Mohamed Nagy Abdel Hay, Amin, Noha Gaber
Format: Article
Language:English
Subjects:
albuminuria
Diabetic nephropathy
neutrophil gelatinase-associated lipocalin
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabetic nephropathy (DN) is a major microvascular diabetic complication representing the key leading reason for end-stage renal disease (ESRD). The current work aimed to evaluate the value of urinary and serum NGAL (neutrophil gelatinase-associating lipocalin), as an early biomarker of DN in subjects with type-2 diabetes mellitus (T2DM). The study included 300 adult subjects with T2DM subdivided into 3 groups: Group A: 100 subjects with normoalbuminuria. Group B: 100 subjects with moderately increased albuminuria. Group C: 100 subjects with severely increased albuminuria. Serum NGAL and urinary NGAL were significantly elevated in T2DMsubjects with albuminuria than in normoalbuminuric T2DMsubjects (p 
ISSN:2090-5068
2090-5076
DOI:10.1080/20905068.2023.2230051