Directing traffic on DNA-How transcription factors relieve or induce transcriptional interference

Transcriptional interference (TI) is increasingly recognized as a widespread mechanism of gene control, particularly given the pervasive nature of transcription, both sense and antisense, across all kingdoms of life. Here, we discuss how transcription factor binding kinetics strongly influence the a...

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Bibliographic Details
Published in:Transcription 2017-03, Vol.8 (2), p.120-125
Main Authors: Hao, Nan, Palmer, Adam C., Dodd, Ian B., Shearwin, Keith E.
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
convergent promoters
dislodgement
DNA - genetics
DNA - metabolism
DNA-binding kinetics
DNA-Directed RNA Polymerases - metabolism
Drosophila
Listeria monocytogenes - genetics
Listeria monocytogenes - metabolism
Models, Molecular
Phosphoglycerate Dehydrogenase - genetics
Phosphoglycerate Dehydrogenase - metabolism
Point-of-View
Promoter Regions, Genetic
roadblock
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Saccharomycetales - genetics
Saccharomycetales - metabolism
Transcription Factors - metabolism
Transcription, Genetic
transcriptional interference
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Summary:Transcriptional interference (TI) is increasingly recognized as a widespread mechanism of gene control, particularly given the pervasive nature of transcription, both sense and antisense, across all kingdoms of life. Here, we discuss how transcription factor binding kinetics strongly influence the ability of a transcription factor to relieve or induce TI.
ISSN:2154-1264
2154-1272
DOI:10.1080/21541264.2017.1285851