Fatigue and body mass index in the Fragile X premutation carrier

Background: Recent evidence has shown that mitochondrial dysfunction may be significant in carriers of the Fragile X premutation. Purpose: The present study examined fatigue severity and body mass index (BMI) (two possible outcomes related to mitochondrial dysfunction) in premutation carriers with a...

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Bibliographic Details
Published in:Fatigue (Abingdon, Eng.) Eng.), 2014-04, Vol.2 (2), p.64-72
Main Authors: Summers, Scott M., Cogswell, Jennifer, Goodrich, John E., Mu, Yi, Nguyen, Danh V., Brass, Steven D., Hagerman, Randi J.
Format: Article
Language:English
Subjects:
body mass index
fatigue
FMR1
Fragile X premutation
Fragile X-associated Tremor Ataxia Syndrome
trinucleotide repeat disorders
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Summary:Background: Recent evidence has shown that mitochondrial dysfunction may be significant in carriers of the Fragile X premutation. Purpose: The present study examined fatigue severity and body mass index (BMI) (two possible outcomes related to mitochondrial dysfunction) in premutation carriers with and without the Fragile X-associated Tremor Ataxia Syndrome (FXTAS) as compared to controls. Methods: Surveys to gather data on height and weight and fatigue impact (Fatigue Severity Scale) were sent out to previous research trial participants with Fragile X premutation-related disorders. Results: On the Fatigue Severity Scale, carriers with and without FXTAS had mean scores of 4.5 (SD 1.9) and 3.8 (SD 1.6), respectively, that differed significantly (p 
ISSN:2164-1846
2164-1862
DOI:10.1080/21641846.2014.881155