Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk

It has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder ca...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2021-02, Vol.17 (2), p.416-417
Main Authors: Fedeli, Ugo, Porreca, Angelo, Colicchia, Michele, Schievano, Elena, Artibani, Walter, Biasio, Luigi Roberto, Palù, Giorgio
Format: Article
Language:English
Subjects:
Administration, Intravesical
Aged
Aged, 80 and over
BCG
BCG Vaccine - administration & dosage
BCG Vaccine - metabolism
bladder Cancer
Covid-19
COVID-19 - epidemiology
COVID-19 - metabolism
COVID-19 - prevention & control
epidemiology
Female
Hospitalization - trends
Humans
Italy - epidemiology
Male
Middle Aged
Risk Factors
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - epidemiology
Urinary Bladder Neoplasms - metabolism
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Summary:It has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder cancer and treated with intra-bladder instillation of BCG, showed no evidence of a protective effect. However, the interpretation of these data need some caution, due to the low prevalence of infection (
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2020.1805994