The interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer

Colorectal cancer (CRC) is one of the most common malignancies and causes of cancer-related mortality worldwide. Cell proliferation and tumor metastasis as well as chemoresistance are correlated with poor survival of CRC. The interferon regulatory factor 6 (IRF6) is functioned as a tumor suppressor...

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Bibliographic Details
Published in:Bioengineered 2022-04, Vol.13 (4), p.10504-10517
Main Authors: Tan, Lin, Qu, Weiming, Wu, Dajun, Liu, Minji, Ai, Qiongjia, Hu, Hongsai, Wang, Qian, Chen, Weishun, Zhou, Hongbing
Format: Article
Language:English
Subjects:
Apoptosis - genetics
Cadherins - genetics
Cadherins - metabolism
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
chemosensitivity
cisplatin
Cisplatin - pharmacology
colorectal cancer
Colorectal Neoplasms - pathology
Gene Expression Regulation, Neoplastic
Humans
Interferon Regulatory Factors - genetics
Interferon Regulatory Factors - metabolism
IRF6
Ki-67 Antigen - metabolism
Liver Neoplasms - drug therapy
Liver Neoplasms - genetics
Research Paper
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Summary:Colorectal cancer (CRC) is one of the most common malignancies and causes of cancer-related mortality worldwide. Cell proliferation and tumor metastasis as well as chemoresistance are correlated with poor survival of CRC. The interferon regulatory factor 6 (IRF6) is functioned as a tumor suppressor gene in several cancers and is associated with risk of CRC. We explored the role of IRF6 in CRC in the present study. The protein expressions of IRF6 in human CRC tissues, normal para-carcinoma tissue and liver metastases from CRC were measured. Cell proliferation, chemotherapeutic sensitivity, cell apoptosis, migration and invasion including the related markers along with IRF6 expression were explored. Our results indicated that IRF6 expression in CRC and liver metastasis were lower than normal tissues, which were correlated positively with E-cadherin and negatively with Ki67 expression in CRC tissue. IRF6 promoted CRC cell sensitivity to cisplatin to suppress cell proliferation, migration and invasion as well as aggravate cell apoptosis. Our study suggested that IRF6 may enhance chemotherapeutic sensitivity of cisplatin mediated by affecting cell proliferation, migration and invasion along with apoptosis through regulating E-cadherin and Ki67, while the identified molecular mechanisms remain to be further explored.
ISSN:2165-5979
2165-5987
DOI:10.1080/21655979.2022.2062103