Cyclodextrin-Promoted Detection of Aromatic Toxicants and Toxicant Metabolites in Urine

Reported herein is the development of a fluorescence-based detection method for aromatic toxicants and toxicant metabolites in urine, using cyclodextrin-promoted energy transfer to high quantumyield fluorophores. This method distinguishes smoker urine from non-smoker urine, enables highly accurate a...

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Bibliographic Details
Published in:Analytical chemistry letters (Online) 2016-07, Vol.6 (4), p.345-353
Main Authors: DiScenza, Dana J., Gareau, Lauren, Serio, Nicole, Roque, John, Prignano, Lindsey, Verderame, Molly, Levine, Mindy
Format: Article
Language:English
Subjects:
Cyclodextrin
fluorescence spectroscopy
polycyclic aromatic hydrocarbons
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Summary:Reported herein is the development of a fluorescence-based detection method for aromatic toxicants and toxicant metabolites in urine, using cyclodextrin-promoted energy transfer to high quantumyield fluorophores. This method distinguishes smoker urine from non-smoker urine, enables highly accurate analyte identification, and leads to micromolar detection limits.
ISSN:2229-7928
2230-7532
DOI:10.1080/22297928.2016.1210021