The Using of Dansyl Chloride for Novel Spectrofluorimetric Determination of Paracetamol in Tablet Dosage Form

A spectrofluorimetric method was developed for the determination of PAR in the authentic form or in its pharmaceutical dosage form. The method was based on the reaction of the drug with 1-dimethyl amino naphthalene-5-sulphonyl chloride (dansyl chloride) in an alkaline medium to form a highly yellow...

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Bibliographic Details
Published in:Analytical chemistry letters (Online) 2021-05, Vol.11 (3), p.427-436
Main Authors: Hasan, Marwa H., El-sadek, Mohamed E., El-Adl, Sobhy M.
Format: Article
Language:English
Subjects:
Dansyl Chloride
Methocarbamol
Methorelax
Paracetamol
Spectrofluorimetric
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Summary:A spectrofluorimetric method was developed for the determination of PAR in the authentic form or in its pharmaceutical dosage form. The method was based on the reaction of the drug with 1-dimethyl amino naphthalene-5-sulphonyl chloride (dansyl chloride) in an alkaline medium to form a highly yellow fluorescent derivative that was measured at 475 nm after excitation at 345 nm. The method was successfully applied to the authentic powder or Paracetamol® tablets and validated in terms of linearity, precision, trueness, limits of quantitation and limits of detection according to ICH guidelines.
ISSN:2229-7928
2230-7532
DOI:10.1080/22297928.2021.1925586