Antifungal and Antioxidant Activities of Piptostigma calophyllum, Uvariodendron calophyllum and Uvariodendron molundense Growing in Cameroon

Fungal infections have substantially increased in number and severity in the last two decades and are generally associated with free radical generation. In a search for plant-derived antifungal and antioxidant agents, ethanolic extracts from Uvariodendron molundense, Uvariodendron calophyllum , and...

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Bibliographic Details
Published in:Journal of biologically active products from nature 2012, Vol.2 (2), p.110-118
Main Authors: Menkem, Elisabeth Zeuko'o, Fokou, Jean-Baptiste Hzounda, Tsague, Ide Flavie Kenfack, Chouadeu, Pascaline Mejiato, Bakarnga-Via, Issakou, Kamdem, Maguerite Simo, Nya, Prosper Biapa, Fokou, Valere Patrick Tsouh, Mofor, Clautilde Teugwa, Boyom, Fabrice Fekam
Format: Article
Language:English
Subjects:
Antifungal
antioxidant
Piptostigma calophyllum
Uvariodendron calophyllum
Uvariodendron molundense
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Summary:Fungal infections have substantially increased in number and severity in the last two decades and are generally associated with free radical generation. In a search for plant-derived antifungal and antioxidant agents, ethanolic extracts from Uvariodendron molundense, Uvariodendron calophyllum , and Piptostigma calophyllum (Annonaceace) were investigated for their antifungal activity against yeasts and moulds, using the agar well diffusion/dilution and the broth microdilution methods and their antioxidant activity, using the DPPH radical scavenging and the metal chelating techniques. Extracts were screened for their phytochemical content. The yield of extraction ranged from 3.72 to 9.51%. All the extracts showed antifungal activity with MIC values ranging 1.30 mg/mL against C. glabrata to 36 mg/mL against Aspergillus fumigatus and Aspergillus flavus . The most potent extract was that of the twigs of U. molundense . The leaf extract of P. calophyllum showed the highest antioxidant activity with a SC ₅₀ of 0.2 mg/mL. The extracts showed potent iron chelation, the most active having an IC ₅₀ of 3.07 mg/mL. Tannins, phenols, and glycosides were found to be commonly present in all the extracts. The results achieved support further investigation of these plants for antifungal and antioxidant agents.
ISSN:2231-1874
2231-1866
2231-1874
DOI:10.1080/22311866.2012.10719117