Bcl-2 proteins: Unraveling the details of a complex and dynamic network

Apoptosis regulation by Bcl-2 proteins is pivotal for mammalians, not only because it is key for development but also because aberrant apoptosis is prerequisite to severe diseases, like cancer. Recently, we quantified interactions within the Bcl-2 protein network in solution and membranes, and addre...

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Bibliographic Details
Published in:Molecular & cellular oncology 2018-01, Vol.5 (1), p.e1384880-e1384880
Main Authors: Bleicken, Stephanie, Garcia-Saez, Ana J.
Format: Article
Language:English
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Bcl-2 proteins
mitochondrial apoptosis
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Summary:Apoptosis regulation by Bcl-2 proteins is pivotal for mammalians, not only because it is key for development but also because aberrant apoptosis is prerequisite to severe diseases, like cancer. Recently, we quantified interactions within the Bcl-2 protein network in solution and membranes, and addressed membrane recruitment, preference of interaction partners and the consequences for Bax activation and inhibition.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2017.1384880