Risk factors associated with bloodstream infections in end-stage renal disease patients: a population-based study

Background: Bloodstream infections (BSI) commonly complicate end-stage renal disease (ESRD) and are the second most common cause of death in these patients. The objective of this study was to define risk factors for development of BSI and its outcome among ESRD patients. Methods: A retrospective, po...

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Published in:Infectious diseases (London, England) England), 2018-12, Vol.50 (11-12), p.831-836
Main Authors: Dagasso, Gabrielle, Conley, Joslyn, Parfitt, Elizabeth, Pasquill, Kelsey, Steele, Lisa, Laupland, Kevin
Format: Article
Language:English
Subjects:
Aged
bacteremia
Bacteremia - complications
Bacteremia - epidemiology
bloodstream infection
British Columbia - epidemiology
Cohort Studies
End-stage renal disease
Escherichia coli - isolation & purification
Escherichia coli Infections - complications
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
fatality
Female
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - epidemiology
Male
Middle Aged
Retrospective Studies
Risk Factors
Staphylococcal Infections - complications
Staphylococcal Infections - epidemiology
Staphylococcus aureus - isolation & purification
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Summary:Background: Bloodstream infections (BSI) commonly complicate end-stage renal disease (ESRD) and are the second most common cause of death in these patients. The objective of this study was to define risk factors for development of BSI and its outcome among ESRD patients. Methods: A retrospective, population-based, matched cohort design was utilized. All adult (18 or older) residents of the western interior of British Columbia with ESRD who had a first BSI between April 2010 and March 2017 were included. Subject cases were then matched 1:1 with an ESRD patient from the regional registry who did not have a BSI. Results: During the study period a total of 53 cases of incident BSI were identified among patients with ESRD. The median age was 70.7 (interquartile range, 61.9-79.6) years and 28 (53%) were male. The most common organism isolated was Staphylococcus aureus (17 cases; 32%). Compared to controls, case patients were significantly (p 
ISSN:2374-4235
2374-4243
DOI:10.1080/23744235.2018.1500707