Tetrazolo[1,5-a]pyrimidine-based metal(II) complexes as therapeutic agents: DNA interaction, targeting topoisomerase I and cyclin-dependent kinase studies

A series of mononuclear nickel(II), copper(II) and zinc(II) complexes of the type [ML 1‒3 Cl 2 ] (1-9) have been synthesized and characterized. All the complexes interact with CT-DNA through groove mode of binding and bring about prominent nuclease activity on plasmid DNA. The complexes strongly inh...

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Bibliographic Details
Published in:Inorganic and nano-metal chemistry 2018-12, Vol.48 (12), p.569-582
Main Authors: Khan Haleel, Azees, Mahendiran, Dharmasivam, Rafi, Ummer Muhammed, Veena, Vijaykumar, Shobana, Sugumar, Rahiman, Aziz Kalilur
Format: Article
Language:English
Subjects:
Apoptosis
DNA binding
DNA cleavage
Molecular docking
Tetrazolo[1,5-a]pyrimidines
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Summary:A series of mononuclear nickel(II), copper(II) and zinc(II) complexes of the type [ML 1‒3 Cl 2 ] (1-9) have been synthesized and characterized. All the complexes interact with CT-DNA through groove mode of binding and bring about prominent nuclease activity on plasmid DNA. The complexes strongly inhibit the topoisomerase I, and also strongly interact with cyclin-dependent kinase receptor. The cytotoxicity activity were assessed aganist three human cancer cell lines such as lung (A549), cervical (HeLa) and colon (HCT-15), in which the complex 5 shows highest activity against the colon (HCT-15) cancer cell. The apoptotic studies were also reported.
ISSN:2470-1556
2470-1564
DOI:10.1080/24701556.2019.1571514