Synthesis, fluorescence, and anticancer activity of silver(I) complex based on 2-hydroxyquinoxaline ligand

The reaction of 2-hydroxyquinoxaline ligand with silver nitrate in anhydrous methanol leaded to the formation of complex [Ag·(L)·(NO 3 )] (1) (L = 2-hydroxyquinoxaline). This complex is characterized by FT-IR spectrometer, elemental analysis, X-ray photoelectron spectroscopy (XPS), and X-ray single-...

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Bibliographic Details
Published in:Inorganic and nano-metal chemistry 2020-04, Vol.50 (4), p.315-320
Main Authors: Li, Shi-Xiong, Chen, Yu-Feng, Lu, Yan, Xu, Shi-Hua, Liao, Bei-Ling
Format: Article
Language:English
Subjects:
2-hydroxyquinoxaline
anticancer activity
Complex
fluorescence
ligand
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Summary:The reaction of 2-hydroxyquinoxaline ligand with silver nitrate in anhydrous methanol leaded to the formation of complex [Ag·(L)·(NO 3 )] (1) (L = 2-hydroxyquinoxaline). This complex is characterized by FT-IR spectrometer, elemental analysis, X-ray photoelectron spectroscopy (XPS), and X-ray single-crystal diffraction. The results show that 1 belongs to the monoclinic, P2 1 /c space group, with a = 13.9949(12) Å, b = 9.2241(7) Å, c = 7.3110(10) Å, α = 90°; β = 101.945(11)°; γ = 90°, V = 923.34(17) Å 3 , Mr = 316.03. The solid-state fluorescence tests show that the fluorescence intensity of 1 is stronger than L, and it is accompanied by a blue shift phenomenon. The activity studies have shown that 1 has good anti-cancer activity with human cancer cells BEL-7404, A549, HepG2, and NCI-H1650, and their IC 50 are less than 15 µg/mL. It can be seen that the silver-based complex not only has a good fluorescence response, but also has good anticancer activity.
ISSN:2470-1556
2470-1564
DOI:10.1080/24701556.2020.1711772