Β N-Alkanoyl-5-Hydroxytryptamines (Cn-5HTs) in Coffee: A Review

Β N-alkanoyl-5-hydroxytryptamines (C n -5HTs) are serotonin amides that contain saturated or unsaturated alkyl long chains. They can be found in the waxy layer that covers the coffee bean and are also present in the coffee brew, one of the most popular beverages in the world. These substances exhibi...

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Bibliographic Details
Published in:Food reviews international 2023-08, Vol.39 (7), p.4761-4780
Main Authors: Brand, A. L. M., Lima, F. A., Tinoco, N. A. B., Mota, J. C., Moreira, I. G. S., Novaes, F. J. M., Garrett, R., Giorno, T. B. S., Fernandes, P. D., Rezende, C. M.
Format: Article
Language:English
Subjects:
5HTs
Amides
Beans
Beverages
Coffee
Food processing
Irritation
N-acylated serotonin
Neuroprotection
Pain perception
Serotonin
stomach-friendly coffee
Vegetable oils
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Summary:Β N-alkanoyl-5-hydroxytryptamines (C n -5HTs) are serotonin amides that contain saturated or unsaturated alkyl long chains. They can be found in the waxy layer that covers the coffee bean and are also present in the coffee brew, one of the most popular beverages in the world. These substances exhibit relevant biological activities, such as antinociceptive and neuroprotective, despite being responsible for the stomach irritation observed in some individuals after drinking coffee. This review depicts the extraction and quantification of C n -5HTs in green and roasted coffee beans, and coffee brew. Additionally, it illustrates the biological activities, synthetic strategies, and products formed during the roasting of the coffee bean, regarding the serotonin amides.
ISSN:8755-9129
1525-6103
DOI:10.1080/87559129.2022.2059807