MOLECULARLY IMPRINTED POLYMER LIBRARY ON A MICROTITER PLATE. HIGH-THROUGHPUT SYNTHESIS AND ASSESSMENT OF CINCHONA ALKALOID-IMPRINTED POLYMERS

A molecularly imprinted polymer library was prepared on a 96-well microtiter plate, using a liquid-handing equipment that was programmed to prepare various breeds of cinchonidine-imprinted polymers. The resultant polymers, immobilized on the bottom surface of the wells, were screened for the binding...

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Bibliographic Details
Published in:Instrumentation science & technology 2001-02, Vol.29 (1), p.1-9
Main Authors: Takeuchi, Toshifumi, Seko, Akinobu, Matsui, Jun, Mukawa, Takashi
Format: Article
Language:English
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Summary:A molecularly imprinted polymer library was prepared on a 96-well microtiter plate, using a liquid-handing equipment that was programmed to prepare various breeds of cinchonidine-imprinted polymers. The resultant polymers, immobilized on the bottom surface of the wells, were screened for the binding capacity by fluorescence measurement, using a microplate reader. Comparison with a conventional assessment by FIA (flow injection analysis) demonstrated the reliability and the high-throughput performance of the microtiter plate-based combinatorial molecular imprinting.
ISSN:1073-9149
1525-6030
DOI:10.1081/CI-100001402