Histological Study of Anophthalmia Observed in Exencephalic Rat Embryos After All-Trans-Retinoic Acid Administration

The purpose of this study is to describe the eye malformations associated with exencephaly observed after retinoic acid (R.A.) administration during gestation in white rat embryos. R.A. suspended in corn oil was given to 13 pregnant rats by gastric intubation. They received various oral doses of R.A...

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Bibliographic Details
Published in:Journal of toxicology. Cutaneous and ocular toxicology 2003-01, Vol.22 (1-2), p.33-46
Main Authors: Emmanouil-Nikoloussi, E. N., Goret-Nicaise, M., Manthos, A., Foroglou, Ch
Format: Article
Language:English
Subjects:
Anophthalmia
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Exencephaly
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Retinoic acid
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Summary:The purpose of this study is to describe the eye malformations associated with exencephaly observed after retinoic acid (R.A.) administration during gestation in white rat embryos. R.A. suspended in corn oil was given to 13 pregnant rats by gastric intubation. They received various oral doses of R.A. (from 0 to 30 mg/kg b.w. a day) from day 7.5 to 11.5 with an additional dose on day 14.5. No abnormalities have been found in the control groups. The embryos from the treated groups showing anophthalmia and exencephaly were chosen for histological study. The microscopic examination points out dose-dependent abnormalities from absence of eye structures to hypoplastic and atypical more or less compact lens vesicle.
ISSN:0731-3829
1532-2505
DOI:10.1081/CUS-120019328