Oral Sustained Delivery of Paracetamol from In Situ Gelling Xyloglucan Formulations

Abstract The purpose of this study was to evaluate the potential of a xyloglucan formulation with in situ gelling properties for the oral sustained delivery of paracetamol. Gelation of dilute aqueous solutions of the polysaccharide xyloglucan occurred in rabbit and rat stomachs as the orally adminis...

Full description

Saved in:
Bibliographic Details
Published in:Drug development and industrial pharmacy 2003-01, Vol.29 (2), p.113-119
Main Authors: Miyazaki, Shozo, Endo, Kumiko, Kawasaki, Naoko, Kubo, Wataru, Watanabe, Hideki, Attwood, David
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Acetaminophen - chemistry
Acetaminophen - pharmacokinetics
Administration, Oral
Analgesics
Animals
Biological and medical sciences
Biological Availability
Chemistry, Pharmaceutical
Delayed-Action Preparations
Drug Carriers
Drug Compounding
Excipients - chemistry
Gels
General pharmacology
Glucans
In situ gelation
In Vitro Techniques
Male
Medical sciences
Neuropharmacology
Oral drug delivery
Paracetamol
Pharmaceutical Solutions
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polysaccharides - chemistry
Rabbits
Rats
Rats, Wistar
Rheology
Solubility
Stomach - metabolism
Suspensions
Sustained release
Viscosity
Xylans
Xyloglucan gels
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The purpose of this study was to evaluate the potential of a xyloglucan formulation with in situ gelling properties for the oral sustained delivery of paracetamol. Gelation of dilute aqueous solutions of the polysaccharide xyloglucan occurred in rabbit and rat stomachs as the orally administered chilled solutions attained body temperature. In vitro studies demonstrated diffusion-controlled release of paracetamol from the gels over a period of 6 hr. The bioavailabilities of paracetamol from the xyloglucan gels formed in situ in the stomachs of rabbits after oral administration of the liquid formulations were similar to that of a commercially available suspension containing an identical dose of paracetamol.
ISSN:0363-9045
1520-5762
DOI:10.1081/DDC-120016718