Novel Effects of On-Chung-Eum, the Traditional Plant Medicine, on Cytokine Production in Human Mononuclear Cells from Behçet's

Plant medications have been used as treatment in various kinds of systemic inflammatory disorder such as Behçet's disease (BD). We investigated the roles of On-Chung-Eum (OCE), a traditional plant medicine, in cytokine regulation of BD. The effects of OCE on cytokine production from phytohaemag...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2003-01, Vol.25 (1), p.65-72
Main Authors: Kim, Mi-Sun, Kim, Sung-Oh, Lim, Woon-Ki, Lee, Jeong-Mi, Hwang, Chung-Yeon, Cho, Kwang-Ho, Kim, Hyung-Min
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Behcet Syndrome - drug therapy
Behcet Syndrome - immunology
Biological and medical sciences
Case-Control Studies
Cyclosporine - pharmacology
Dose-Response Relationship, Drug
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Enzyme-Linked Immunosorbent Assay
Female
General pharmacology
Humans
Immunocompromised Host
Interferon-gamma - biosynthesis
Interleukin-1 - biosynthesis
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - metabolism
Male
Medical sciences
Middle Aged
Neurotoxicity Syndromes
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytohemagglutinins - pharmacology
Phytotherapy
Tumor Necrosis Factor-alpha - biosynthesis
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Summary:Plant medications have been used as treatment in various kinds of systemic inflammatory disorder such as Behçet's disease (BD). We investigated the roles of On-Chung-Eum (OCE), a traditional plant medicine, in cytokine regulation of BD. The effects of OCE on cytokine production from phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) of Behçet's patients and control subjects were measured by ELISA. PBMC from patients with active BD produced higher levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) compared to control. OCE significantly inhibited the production of TNF-α, IL-1β and interferon-γ (INF-γ) compared to absence of OCE. The inhibitory effects of OCE showed in a dose-dependent manner, and OCE had better effects than immunosuppressive drug, cyclosporin A. OCE is able to effectively inhibit proinflammatory cytokines and immunoregulatory Th1 cytokine. OCE treatment for BD patients may help the improvement of symptoms through cytokine modulation.
ISSN:0892-3973
1532-2513
DOI:10.1081/IPH-120018284