SIZE CHARACTERIZATION OF CORE-SHELL POLY(L-LACTIDE) MICROSPHERES BY FLOW/HYPERLAYER FIELD-FLOW FRACTIONATION

Flow/hyperlayer field flow fractionation (Fl/Hy FFF) has been applied for the rapid separation and size characterization of core-shell type poly(l-lactide) (PLLA) microspheres which are widely studied as a potential drug carrier due to its biodegradability. Examined microspheres are prepared by vary...

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Bibliographic Details
Published in:Journal of liquid chromatography & related technologies 1999-01, Vol.22 (18), p.2729-2740
Main Authors: Hee Moon, Myeong, Kim, Keummi, Byun, Youngro, Pyo, Dongjin
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Exact sciences and technology
General pharmacology
Medical sciences
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
Structure, morphology and analysis
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Summary:Flow/hyperlayer field flow fractionation (Fl/Hy FFF) has been applied for the rapid separation and size characterization of core-shell type poly(l-lactide) (PLLA) microspheres which are widely studied as a potential drug carrier due to its biodegradability. Examined microspheres are prepared by varying the entrapped amount of the retinoic acid as an anti-cancer therapeutic and varying PEG-PLLA copolymers. It is demonstrated that the separation of PLLA microspheres can be achieved within 5 min. by Fl/Hy FFF and the particle size distribution (PSD) is readily obtained from the experimental fractograms. From the size distribution of PLLA particles obtained by Fl/Fl FFF, it is shown that PSD increases with the amount of drug loaded but it does not seriously change with the addition of PEG-PLLA copolymers.
ISSN:1082-6076
1520-572X
DOI:10.1081/JLC-100102054