SYNTHESIS OF MODIFIED NUCLEOSIDE 5′-TRIPHOSPHATES FOR IN VITRO SELECTION OF CATALYTIC NUCLEIC ACIDS [1]

2′-Modified pyrimidine nucleoside 5′-triphosphates comprising amino, imidazole and carboxylate functionality attached to the 5-position of the base were synthesized. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2001-04, Vol.20 (4-7), p.1113-1115
Main Authors: Matulic-Adamic, Jasenka, Daniher, Andrew T., Karpeisky, Alexander, Haeberli, Peter, Sweedler, David, Beigelman, Leonid
Format: Article
Language:English
Subjects:
Drug Stability
Pyrimidine Nucleotides - chemical synthesis
Pyrimidine Nucleotides - chemistry
RNA, Catalytic - chemistry
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Description
Summary:2′-Modified pyrimidine nucleoside 5′-triphosphates comprising amino, imidazole and carboxylate functionality attached to the 5-position of the base were synthesized. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-100002500