Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

The stabilizing properties of LNA and α-l-LNA oligonucleotides against endo- and 3′-exonucleases have been evaluated.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.1041-1043
Main Authors: Frieden, Miriam, Hansen, Henrik F., Koch, Troels
Format: Article
Language:English
Subjects:
DNA - chemistry
Drug Stability
Endoribonucleases - metabolism
Exonucleases - metabolism
LNA
Nuclease stability
Oligodeoxyribonucleotides - chemistry
Oligonucleotides
Oligonucleotides, Antisense - chemistry
Phosphodiesterase I
Substrate Specificity
α-L-LNA
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Description
Summary:The stabilizing properties of LNA and α-l-LNA oligonucleotides against endo- and 3′-exonucleases have been evaluated.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-120022731