GTP Concentrations are Elevated in Erythrocytes of Renal Transplant Recipients when Conventional Immunosuppression is Replaced by the Inosine Monophosphate Dehydrogenase Inhibitor Mycophenolic Acid Mofetil (MMF)

We show that GTP concentrations rise in the erythrocytes of renal transplant recipients receiving the immunosuppressant MMF, and demonstrate that this effect is not caused by poor renal function after engraftment. We propose a model that is consistent with our observations.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2004-10, Vol.23 (8-9), p.1407-1409
Main Authors: Goldsmith, D. J. A., Carrey, E. A., Edbury, S. M., Marinaki, A. M., Simmonds, H. A.
Format: Article
Language:English
Subjects:
Azathioprine - pharmacology
Binding Sites
Chromatography, High Pressure Liquid
Creatinine - blood
Enzyme Inhibitors - pharmacology
Erythrocytes - metabolism
Graft Rejection
GTP
Guanosine Triphosphate - metabolism
Humans
Immunosuppressant
Immunosuppressive Agents - pharmacology
IMP Dehydrogenase - antagonists & inhibitors
Kidney Transplantation
MMF
Mycophenolic acid
Renal transplant
Time Factors
Up-Regulation
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Description
Summary:We show that GTP concentrations rise in the erythrocytes of renal transplant recipients receiving the immunosuppressant MMF, and demonstrate that this effect is not caused by poor renal function after engraftment. We propose a model that is consistent with our observations.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-200027645