RESOLUTION OF CHIRAL ALIPHATIC AND ARYLALKYL AMINES USING IMMOBILIZED CANDIDA ANTARCTICA LIPASE AND ISOLATION OF THEIR R- AND S-ENANTIOMERS

The resolution of chiral aliphatic and arylalkyl amines in high enantiomeric excess (up to 97.5% ee for the R-enantiomers and up to 99.9% ee for the S-enantiomers) and good yield (50-80%) using immobilized Candida antarctica lipase and ethyl acetate as acyl donor has been demonstrated. A second reso...

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Bibliographic Details
Published in:Synthetic communications 2001-01, Vol.31 (4), p.569-578
Main Authors: Davis, Bruce A., Durden, David A.
Format: Article
Language:English
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Summary:The resolution of chiral aliphatic and arylalkyl amines in high enantiomeric excess (up to 97.5% ee for the R-enantiomers and up to 99.9% ee for the S-enantiomers) and good yield (50-80%) using immobilized Candida antarctica lipase and ethyl acetate as acyl donor has been demonstrated. A second resolution on the R-amine increased the enantiomeric excess to more than 99.5% (up to 99.9%).
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-100000584