SYNTHESIS OF 5-P-[N-(2-PYRROLIDINONE)]PHENYL-10,15,20-TRIPHENYLPORPHYRIN

5-p-[N-(2-Pyrrolidinone)]phenyl-10,15,20-triphenylporphyrin 3, a novel potential photodynamic therapy drug, was synthesized in high yield in two steps starting from aminotetraphenylporphyrin 1 by first introduction of a chlorobutyramido group, then intramolecular cyclization under base conditions.

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Bibliographic Details
Published in:Synthetic communications 2001-01, Vol.31 (13), p.1941-1945
Main Authors: Cheng, Hao, Ma, Jin Shi, Zhang, De He, Chen, Qing Qi
Format: Article
Language:English
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Summary:5-p-[N-(2-Pyrrolidinone)]phenyl-10,15,20-triphenylporphyrin 3, a novel potential photodynamic therapy drug, was synthesized in high yield in two steps starting from aminotetraphenylporphyrin 1 by first introduction of a chlorobutyramido group, then intramolecular cyclization under base conditions.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-100104409