A NOVEL AND EFFICIENT SYNTHESIS OF 4-PHENYL-2-CHLOROPYRIMIDINES FROM ACETOPHENONE CYANOIMINES

A versatile and efficient 2 step synthesis of 4-phenyl-2-chloropyrimidines is described. The reaction proceeds by treatment of acetophenone cyanoimines under Vilsmeier-Haack conditions to give the target compounds in moderate yields.

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Bibliographic Details
Published in:Synthetic communications 2002-01, Vol.32 (19), p.3011-3018
Main Authors: Cuccia, Salvatore J., Fleming, Linda B., France, Donald J.
Format: Article
Language:English
Subjects:
Acetophenone
Pyrimidine
Vilsmeier
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Description
Summary:A versatile and efficient 2 step synthesis of 4-phenyl-2-chloropyrimidines is described. The reaction proceeds by treatment of acetophenone cyanoimines under Vilsmeier-Haack conditions to give the target compounds in moderate yields.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120012991