Synthesis of Doxorubicin Conjugates Through Hydrazone Bonds to Melanotransferrin P97

Through hydrazone bonds, three doxorubicin-p97 conjugates 5, 9, 12 are synthesized using adipic dihydrazine, 4-(4-N-maleimidophenyl)-butyric acid hydrazine 6 and adipic acid mono hydrazine 10 as linkers. These are potential agents for treating brain tumors.

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Bibliographic Details
Published in:Synthetic communications 2003-01, Vol.33 (14), p.2377-2390
Main Authors: Chen, Qingqi, Sowa, Damian A., Cai, Jianlin, Gabathuler, Reinhard
Format: Article
Language:English
Subjects:
Anticancer drug
Bioconjugate
Blood-brain barrier
Brain tumor
Cross-linking
Doxorubicin
Drug delivery
Hydrazone linker
Protein carrier
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Description
Summary:Through hydrazone bonds, three doxorubicin-p97 conjugates 5, 9, 12 are synthesized using adipic dihydrazine, 4-(4-N-maleimidophenyl)-butyric acid hydrazine 6 and adipic acid mono hydrazine 10 as linkers. These are potential agents for treating brain tumors.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120021827