Synthesis of Doxorubicin Conjugates Through Hydrazone Bonds to Melanotransferrin P97

Through hydrazone bonds, three doxorubicin-p97 conjugates 5, 9, 12 are synthesized using adipic dihydrazine, 4-(4-N-maleimidophenyl)-butyric acid hydrazine 6 and adipic acid mono hydrazine 10 as linkers. These are potential agents for treating brain tumors.

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Published in:Synthetic communications 2003-01, Vol.33 (14), p.2377-2390
Main Authors: Chen, Qingqi, Sowa, Damian A., Cai, Jianlin, Gabathuler, Reinhard
Format: Article
Language:English
Subjects:
Anticancer drug
Bioconjugate
Blood-brain barrier
Brain tumor
Cross-linking
Doxorubicin
Drug delivery
Hydrazone linker
Protein carrier
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cited_by cdi_FETCH-LOGICAL-c284t-182fd11d070eafb448f54ef7232f5b20579634e10021feb20bb551f12fb2a0df3
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description Through hydrazone bonds, three doxorubicin-p97 conjugates 5, 9, 12 are synthesized using adipic dihydrazine, 4-(4-N-maleimidophenyl)-butyric acid hydrazine 6 and adipic acid mono hydrazine 10 as linkers. These are potential agents for treating brain tumors.
doi_str_mv 10.1081/SCC-120021827
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source Taylor and Francis Science and Technology Collection
subjects Anticancer drug
Bioconjugate
Blood-brain barrier
Brain tumor
Cross-linking
Doxorubicin
Drug delivery
Hydrazone linker
Protein carrier
title Synthesis of Doxorubicin Conjugates Through Hydrazone Bonds to Melanotransferrin P97
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