Synthesis of Doxorubicin Conjugates Through 14-Hydroxy Group to Melanotransferrin P97

Using Fmoc to protect the amino group, Fmoc-doxorubicin is conjugated through the 14-hydroxy group to the amino group of melanotransferrin p97 by spacer arms such as succinate and glutarate. The Fmoc group is then removed under basic conditions, which affords doxorubicin-p97 conjugates. The resultin...

Full description

Saved in:
Bibliographic Details
Published in:Synthetic communications 2003-01, Vol.33 (14), p.2391-2400
Main Authors: Chen, Qingqi, Sowa, Damian A., Gabathuler, Reinhard
Format: Article
Language:English
Subjects:
Anticancer drug
Bioconjugate
Blood-brain barrier
Brain tumor
Cross-linking
Doxorubicin
Drug delivery
Ester bond linkage
Protein carrier
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Using Fmoc to protect the amino group, Fmoc-doxorubicin is conjugated through the 14-hydroxy group to the amino group of melanotransferrin p97 by spacer arms such as succinate and glutarate. The Fmoc group is then removed under basic conditions, which affords doxorubicin-p97 conjugates. The resulting bioconjugates are potential agents for treating brain tumors.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120021828