An Efficient One-Pot Synthesis of N-Methoxy-N-methylamides from Carboxylic Acids

Several N-methoxy-N-methylamides were prepared by the reaction of the corresponding carboxylic acids with N,O-dimethylhydroxylamine hydrochloride at room temperature using trichloromethyl chloroformate in the presence of triethylamine in excellent yields.

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Bibliographic Details
Published in:Synthetic communications 2003-12, Vol.33 (23), p.4013-4018
Main Authors: Kim, Misoo, Lee, Hagyoung, Han, Ki-Jong, Kay, Kwang-Yol
Format: Article
Language:English
Subjects:
Carboxylic acids
N,O-Dimethyl-hydroxylamine hydrochloride
N-Methoxy-N-methylamides
Trichloromethyl chloroformate
Weinreb amides
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Description
Summary:Several N-methoxy-N-methylamides were prepared by the reaction of the corresponding carboxylic acids with N,O-dimethylhydroxylamine hydrochloride at room temperature using trichloromethyl chloroformate in the presence of triethylamine in excellent yields.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120026336