A Unified Synthesis of Bifunctional 4-Substituted-1,2,3,4-tetrahydroisoquinoline Derivatives

Starting from a single, commercially available bromoisoquinoline, convenient (multigram) syntheses of 4-substituted-1,2,3,4-tetrahydroisoquinoline derivatives have been developed. The compounds thus prepared show suitable substitution patterns for further derivatization and constitute a new family o...

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Bibliographic Details
Published in:Synthetic communications 2004-12, Vol.34 (1), p.137-149
Main Authors: Carmen Bernabeu, M., Luis Díaz, José, Jiménez, Oscar, Lavilla, Rodolfo
Format: Article
Language:English
Subjects:
Combinatorial chemistry
Copper
Hydrogenation
Nucleophilic aromatic substitutions
Protecting groups
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Summary:Starting from a single, commercially available bromoisoquinoline, convenient (multigram) syntheses of 4-substituted-1,2,3,4-tetrahydroisoquinoline derivatives have been developed. The compounds thus prepared show suitable substitution patterns for further derivatization and constitute a new family of compounds of potential pharmacological interest.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120027247