One-Pot Synthesis of Pyrazole-5(3)-carboxyamides

A convenient one-pot synthesis of eight pyrazole-5(3)-carboxyamides from the reaction of the 5(3)-trichloromethylpyrazoles with amines, in good yield, is reported. These reactions show that the trichloromethyl group is a convenient precursor to carboxyamide groups.

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Bibliographic Details
Published in:Synthetic communications 2004-12, Vol.34 (10), p.1915-1923
Main Authors: Martins, Marcos A. P., Emmerich, Daniel, Beck, Paulo, Cunico, Wilson, Pereira, Claudio M. P., Sinhorin, Adilson P., Brondani, Sergio, Peres, Rodrigo, Teixeira, Marcos V. M., Bonacorso, Helio G., Zanatta, Nilo
Format: Article
Language:English
Subjects:
Amides
Enones
Halogen compounds
Pyrazoles
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Summary:A convenient one-pot synthesis of eight pyrazole-5(3)-carboxyamides from the reaction of the 5(3)-trichloromethylpyrazoles with amines, in good yield, is reported. These reactions show that the trichloromethyl group is a convenient precursor to carboxyamide groups.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120034176